This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4jzc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4jzc is ON HOLD Authors: Yu, X., Seegar, T.C.M., Dalton, A.C., Tzvetkova-Robev, D., Goldgur, Y., Nikolov, D.B., Barton, W.A. Description: Angiopoie...) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Angiopoietin-2 fibrinogen domain TAG mutant== | |
| - | + | <StructureSection load='4jzc' size='340' side='right'caption='[[4jzc]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4jzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JZC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jzc OCA], [https://pdbe.org/4jzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jzc RCSB], [https://www.ebi.ac.uk/pdbsum/4jzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jzc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Barton WA]] | ||
| + | [[Category: Dalton AC]] | ||
| + | [[Category: Goldgur Y]] | ||
| + | [[Category: Nikolov DB]] | ||
| + | [[Category: Seegar TCM]] | ||
| + | [[Category: Tzvetkova-Robev D]] | ||
| + | [[Category: Yu X]] | ||
Current revision
Angiopoietin-2 fibrinogen domain TAG mutant
| |||||||||||
