4ezn

{{STRUCTURE_4ezn| PDB=4ezn | SCENE= }}

===Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin===

{{ABSTRACT_PUBMED_23562829}}

==Function==

[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/PYRRH_PYRAP PYRRH_PYRAP]] Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

==About this Structure==

[[4ezn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZN OCA].

[[Category: Escherichia coli k-12]]

[[Category: Straeter, N.]]

[[Category: Zahn, M.]]

[[Category: Chaperone]]

[[Category: Chaperone-peptide binding protein complex]]

[[Category: Peptide binding]]