2ery
From Proteopedia
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| - | [[Image:2ery.gif|left|200px]]<br /><applet load="2ery" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2ery, resolution 1.70Å" /> | ||
| - | '''The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state'''<br /> | ||
| - | == | + | ==The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state== |
| - | + | <StructureSection load='2ery' size='340' side='right'caption='[[2ery]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERY FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [https://pdbe.org/2ery PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB], [https://www.ebi.ac.uk/pdbsum/2ery PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ery ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[https://omim.org/entry/167000 167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2ery_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ery ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Burgess | + | [[Category: Burgess N]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Salah E]] |
| - | + | [[Category: Schoch G]] | |
| - | [[Category: Salah | + | [[Category: Soundararajan M]] |
| - | [[Category: Schoch | + | [[Category: Sundstrom M]] |
| - | [[Category: Soundararajan | + | [[Category: Turnbull A]] |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Turnbull | + | [[Category: Von Delft F]] |
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Current revision
The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Burgess N | Doyle D | Edwards A | Elkins J | Gileadi C | Gileadi O | Papagrigoriou E | Salah E | Schoch G | Soundararajan M | Sundstrom M | Turnbull A | Weigelt J | Von Delft F
