3mpx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3mpx" [edit=sysop:move=sysop])
Current revision (09:26, 30 October 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3mpx| PDB=3mpx | SCENE= }}
 
-
===Crystal structure of the DH and PH-1 domains of human FGD5===
 
-
==Function==
+
==Crystal structure of the DH and PH-1 domains of human FGD5==
-
[[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
+
<StructureSection load='3mpx' size='340' side='right'caption='[[3mpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[3mpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPX FirstGlance]. <br>
-
[[3mpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpx OCA], [https://pdbe.org/3mpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mpx RCSB], [https://www.ebi.ac.uk/pdbsum/3mpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpx ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mpx_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mpx ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bochkarev A]]
-
[[Category: Crombet, L.]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M.]]
+
[[Category: Crombet L]]
-
[[Category: Nedyalkova, L.]]
+
[[Category: Edwards AM]]
-
[[Category: Park, H.]]
+
[[Category: Nedyalkova L]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Park H]]
-
[[Category: Shen, Y.]]
+
[[Category: Shen Y]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Tong, Y.]]
+
[[Category: Tong Y]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Dh domain]]
+
-
[[Category: Lipid binding protein]]
+
-
[[Category: Ph domain]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

Crystal structure of the DH and PH-1 domains of human FGD5

PDB ID 3mpx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mpx"
Personal tools