2l4t
From Proteopedia
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| - | {{STRUCTURE_2l4t| PDB=2l4t | SCENE= }} | ||
| - | ===GIP/Glutaminase L peptide complex=== | ||
| - | {{ABSTRACT_PUBMED_21417405}} | ||
| - | == | + | ==GIP/Glutaminase L peptide complex== |
| - | [[http://www.uniprot.org/uniprot/TX1B3_HUMAN TX1B3_HUMAN | + | <StructureSection load='2l4t' size='340' side='right'caption='[[2l4t]]' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2l4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4T FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4t OCA], [https://pdbe.org/2l4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4t RCSB], [https://www.ebi.ac.uk/pdbsum/2l4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4t ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/TX1B3_HUMAN TX1B3_HUMAN] May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:10940294</ref> <ref>PMID:16855024</ref> <ref>PMID:21139582</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Banerjee | + | [[Category: Large Structures]] |
| - | [[Category: Bhaskaran | + | [[Category: Banerjee M]] |
| - | [[Category: Mohanty | + | [[Category: Bhaskaran R]] |
| - | [[Category: Ovee | + | [[Category: Mohanty S]] |
| - | [[Category: Zoetewey | + | [[Category: Ovee M]] |
| - | + | [[Category: Zoetewey DL]] | |
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Current revision
GIP/Glutaminase L peptide complex
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