2x4x

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{{STRUCTURE_2x4x| PDB=2x4x | SCENE= }}
 
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===MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BY THE PWWP DOMAIN OF BRPF1.===
 
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{{ABSTRACT_PUBMED_20400950}}
 
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==Function==
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==Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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<StructureSection load='2x4x' size='340' side='right'caption='[[2x4x]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x4x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4x OCA], [https://pdbe.org/2x4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4x RCSB], [https://www.ebi.ac.uk/pdbsum/2x4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.
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==About this Structure==
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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.,Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Gottgens B, Bycroft M Nat Struct Mol Biol. 2010 May;17(5):617-9. Epub 2010 Apr 18. PMID:20400950<ref>PMID:20400950</ref>
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[[2x4x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4X OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020400950</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 2x4x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peregrin|Peregrin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allen, M D.]]
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[[Category: Large Structures]]
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[[Category: Bonadies, N.]]
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[[Category: Allen MD]]
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[[Category: Bycroft, M.]]
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[[Category: Bonadies N]]
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[[Category: Freund, S M.V.]]
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[[Category: Bycroft M]]
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[[Category: Gottgens, B.]]
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[[Category: Freund SMV]]
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[[Category: Huntly, B J.P.]]
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[[Category: Gottgens B]]
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[[Category: Kvinlaug, B.]]
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[[Category: Huntly BJP]]
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[[Category: Santiveri, C M.]]
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[[Category: Kvinlaug B]]
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[[Category: Vezzoli, A.]]
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[[Category: Santiveri CM]]
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[[Category: Chromatin regulator]]
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[[Category: Vezzoli A]]
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[[Category: Metal-binding]]
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[[Category: Nucleosome]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.

PDB ID 2x4x

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