3n7q

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{{STRUCTURE_3n7q| PDB=3n7q | SCENE= }}
 
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===Crystal structure of human mitochondrial mTERF fragment (aa 99-399) in complex with a 12-mer DNA encompassing the tRNALeu(UUR) binding sequence===
 
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{{ABSTRACT_PUBMED_20543826}}
 
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==Function==
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==Crystal structure of human mitochondrial mTERF fragment (aa 99-399) in complex with a 12-mer DNA encompassing the tRNALeu(UUR) binding sequence==
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[[http://www.uniprot.org/uniprot/MTERF_HUMAN MTERF_HUMAN]] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity.<ref>PMID:20550934</ref>
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<StructureSection load='3n7q' size='340' side='right'caption='[[3n7q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3n7q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7Q FirstGlance]. <br>
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[[3n7q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Q OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7q OCA], [https://pdbe.org/3n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7q RCSB], [https://www.ebi.ac.uk/pdbsum/3n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7q ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020543826</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTEF1_HUMAN MTEF1_HUMAN] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.<ref>PMID:20550934</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7q ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arnan, C.]]
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[[Category: Large Structures]]
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[[Category: Bernado, P.]]
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[[Category: Arnan C]]
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[[Category: Coll, M.]]
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[[Category: Bernado P]]
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[[Category: Fernandez-Millan, P.]]
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[[Category: Coll M]]
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[[Category: Jacobs, H T.]]
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[[Category: Fernandez-Millan P]]
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[[Category: Jimenez-Menendez, N.]]
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[[Category: Jacobs HT]]
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[[Category: Montoya, J.]]
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[[Category: Jimenez-Menendez N]]
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[[Category: Rubio-Cosials, A.]]
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[[Category: Montoya J]]
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[[Category: Sola, M.]]
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[[Category: Rubio-Cosials A]]
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[[Category: Uson, I.]]
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[[Category: Sola M]]
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[[Category: Left-handed helical tandem repeat]]
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[[Category: Uson I]]
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[[Category: Mitochondrial replication pausing-dna complex]]
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[[Category: Mitochondrial transcription termination factor-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: Replication-dna complex]]
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[[Category: Transcription]]
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Current revision

Crystal structure of human mitochondrial mTERF fragment (aa 99-399) in complex with a 12-mer DNA encompassing the tRNALeu(UUR) binding sequence

PDB ID 3n7q

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