3n89

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{{STRUCTURE_3n89| PDB=3n89 | SCENE= }}
 
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===KH domains===
 
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{{ABSTRACT_PUBMED_20823118}}
 
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==Function==
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==KH domains==
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[[http://www.uniprot.org/uniprot/Q95ZK7_CAEEL Q95ZK7_CAEEL]] Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.<ref>PMID:12431376</ref> <ref>PMID:15454534</ref> <ref>PMID:19461891</ref>
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<StructureSection load='3n89' size='340' side='right'caption='[[3n89]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3n89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N89 FirstGlance]. <br>
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[[3n89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N89 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.789&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n89 OCA], [https://pdbe.org/3n89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n89 RCSB], [https://www.ebi.ac.uk/pdbsum/3n89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n89 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:020823118</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/GLD3_CAEEL GLD3_CAEEL] Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.<ref>PMID:12431376</ref> <ref>PMID:15454534</ref> <ref>PMID:19461891</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/3n89_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n89 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Bonneau, F.]]
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[[Category: Large Structures]]
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[[Category: Conti, E.]]
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[[Category: Bonneau F]]
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[[Category: Eckmann, C R.]]
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[[Category: Conti E]]
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[[Category: Hartung, S A.]]
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[[Category: Eckmann CR]]
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[[Category: Nakel, K.]]
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[[Category: Hartung SA]]
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[[Category: Cell cycle]]
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[[Category: Nakel K]]
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[[Category: Germline development]]
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[[Category: Kh domain]]
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[[Category: Rna binding]]
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Current revision

KH domains

PDB ID 3n89

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OCA

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