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3mtl

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{{STRUCTURE_3mtl| PDB=3mtl | SCENE= }}
 
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===Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804===
 
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==Function==
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==Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804==
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[[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>
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<StructureSection load='3mtl' size='340' side='right'caption='[[3mtl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mtl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MTL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtl OCA], [https://pdbe.org/3mtl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mtl RCSB], [https://www.ebi.ac.uk/pdbsum/3mtl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mtl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mtl ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3mtl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTL OCA].
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Cyclin-dependent kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amos, A.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Amos A]]
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[[Category: Ayinampudi, V.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Ayinampudi V]]
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[[Category: Bountra, C.]]
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[[Category: Berridge G]]
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[[Category: Bullock, A.]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Bullock A]]
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[[Category: Das, S.]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von.]]
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[[Category: Das S]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov O]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates, T.]]
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[[Category: Keates T]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Muniz, J.]]
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[[Category: Muniz J]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Rellos, P.]]
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[[Category: Rellos P]]
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[[Category: Roos, A.]]
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[[Category: Roos A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Sharpe TD]]
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[[Category: Sharpe, T D.]]
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[[Category: Thangaratnarajah C]]
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[[Category: Thangaratnarajah, C.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yue W]]
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[[Category: Yue, W.]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y.]]
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[[Category: Von Delft F]]
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[[Category: Indirubin]]
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[[Category: Kinase]]
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[[Category: Pctaire1]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804

PDB ID 3mtl

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