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3mff

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{{STRUCTURE_3mff| PDB=3mff | SCENE= }}
 
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===1F1E8hu TCR===
 
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{{ABSTRACT_PUBMED_020630474}}
 
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==About this Structure==
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==1F1E8hu TCR==
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[[3mff]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFF OCA].
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<StructureSection load='3mff' size='340' side='right'caption='[[3mff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3mff]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MFF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mff OCA], [http://pdbe.org/3mff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mff RCSB], [http://www.ebi.ac.uk/pdbsum/3mff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mff ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/3mff_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mff ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Alphabeta T-cell receptors (TcRs) play a central role in cellular immune response. They are members of the Ig superfamily, with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type domain. We have determined the ectodomain structure of an alphabeta TcR, which recognizes the autoantigen myelin basic protein. The 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and C(beta) domains, but the C(alpha) domain exhibits a main-chain conformation remarkably different from those previously reported for TcR crystal structures. The global IgC-like fold is maintained, but a piston-like rearrangement between BC and DE beta-turns results in beta-strand slippage. This substantial conformational change may represent a signaling intermediate. Our structure is the first example for the Ig fold of the increasingly recognized concept of "metamorphic proteins."
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An alternative conformation of the T-cell receptor alpha constant region.,van Boxel GI, Holmes S, Fugger L, Jones EY J Mol Biol. 2010 Jul 23;400(4):828-37. Epub 2010 May 31. PMID:20630474<ref>PMID:20630474</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3mff" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[T-cell receptor|T-cell receptor]]
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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[[Category: Homo sapiens]]
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== References ==
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[[Category: Boxel, G I.van.]]
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<references/>
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[[Category: Fugger, L.]]
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__TOC__
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[[Category: Holmes, S.]]
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</StructureSection>
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[[Category: Jones, E Y.]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Boxel, G I.van]]
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[[Category: Fugger, L]]
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[[Category: Holmes, S]]
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[[Category: Jones, E Y]]
[[Category: Alpha constant domain]]
[[Category: Alpha constant domain]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Protein metamorphism]]
[[Category: Protein metamorphism]]
[[Category: T-cell receptor]]
[[Category: T-cell receptor]]

Current revision

1F1E8hu TCR

PDB ID 3mff

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