This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3n9m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:32, 20 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3n9m| PDB=3n9m | SCENE= }}
 
-
===ceKDM7A from C.elegans, alone===
 
-
{{ABSTRACT_PUBMED_20567261}}
 
-
==Function==
+
==ceKDM7A from C.elegans, alone==
-
[[http://www.uniprot.org/uniprot/Q9GYI0_CAEEL Q9GYI0_CAEEL]] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
+
<StructureSection load='3n9m' size='340' side='right'caption='[[3n9m]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[3n9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N9M FirstGlance]. <br>
-
[[3n9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.493&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9m OCA], [https://pdbe.org/3n9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n9m RCSB], [https://www.ebi.ac.uk/pdbsum/3n9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9m ProSAT]</span></td></tr>
-
<ref group="xtra">PMID:020567261</ref><references group="xtra"/><references/>
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM7_CAEEL KDM7_CAEEL] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n9/3n9m_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n9m ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
-
[[Category: Chen, C D.]]
+
[[Category: Large Structures]]
-
[[Category: Hou, H.]]
+
[[Category: Chen CD]]
-
[[Category: Hu, L.]]
+
[[Category: Hou H]]
-
[[Category: Wang, P.]]
+
[[Category: Hu L]]
-
[[Category: Xu, Y.]]
+
[[Category: Wang P]]
-
[[Category: Yang, Y.]]
+
[[Category: Xu Y]]
-
[[Category: Demethylase]]
+
[[Category: Yang Y]]
-
[[Category: Histone]]
+
-
[[Category: Jmjc]]
+
-
[[Category: Methylation]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Phd]]
+

Current revision

ceKDM7A from C.elegans, alone

PDB ID 3n9m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3n9m"
Personal tools