3n9m

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{{STRUCTURE_3n9m| PDB=3n9m | SCENE= }}
 
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===ceKDM7A from C.elegans, alone===
 
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{{ABSTRACT_PUBMED_20567261}}
 
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==Function==
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==ceKDM7A from C.elegans, alone==
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[[http://www.uniprot.org/uniprot/Q9GYI0_CAEEL Q9GYI0_CAEEL]] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
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<StructureSection load='3n9m' size='340' side='right'caption='[[3n9m]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3n9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N9M FirstGlance]. <br>
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[[3n9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9M OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.493&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9m OCA], [https://pdbe.org/3n9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n9m RCSB], [https://www.ebi.ac.uk/pdbsum/3n9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9m ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020567261</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM7_CAEEL KDM7_CAEEL] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n9/3n9m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n9m ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Chen, C D.]]
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[[Category: Large Structures]]
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[[Category: Hou, H.]]
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[[Category: Chen CD]]
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[[Category: Hu, L.]]
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[[Category: Hou H]]
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[[Category: Wang, P.]]
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[[Category: Hu L]]
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[[Category: Xu, Y.]]
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[[Category: Wang P]]
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[[Category: Yang, Y.]]
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[[Category: Xu Y]]
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[[Category: Demethylase]]
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[[Category: Yang Y]]
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[[Category: Histone]]
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[[Category: Jmjc]]
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[[Category: Methylation]]
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[[Category: Oxidoreductase]]
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[[Category: Phd]]
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Current revision

ceKDM7A from C.elegans, alone

PDB ID 3n9m

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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