2zrw

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{{STRUCTURE_2zrw| PDB=2zrw | SCENE= }}
 
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===Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP.===
 
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{{ABSTRACT_PUBMED_19158086}}
 
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==Function==
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==Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP.==
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[[http://www.uniprot.org/uniprot/IDI2_SULSH IDI2_SULSH]] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity).
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<StructureSection load='2zrw' size='340' side='right'caption='[[2zrw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_shibatae Saccharolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPR:ISOPENTYL+PYROPHOSPHATE'>IPR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zrw OCA], [https://pdbe.org/2zrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zrw RCSB], [https://www.ebi.ac.uk/pdbsum/2zrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zrw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDI2_SACSH IDI2_SACSH] Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).[HAMAP-Rule:MF_00354]<ref>PMID:19158086</ref> <ref>PMID:22158896</ref> <ref>PMID:22505674</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zrw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zrw ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[2zrw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_shibatae Sulfolobus shibatae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRW OCA].
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*[[Isopentenyl-diphosphate delta-isomerase|Isopentenyl-diphosphate delta-isomerase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019158086</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Isopentenyl-diphosphate Delta-isomerase]]
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</StructureSection>
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[[Category: Sulfolobus shibatae]]
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[[Category: Large Structures]]
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[[Category: Hemmi, H.]]
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[[Category: Saccharolobus shibatae]]
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[[Category: Ikeda, Y.]]
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[[Category: Hemmi H]]
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[[Category: Kusunoki, M.]]
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[[Category: Ikeda Y]]
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[[Category: Nakayama, T.]]
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[[Category: Kusunoki M]]
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[[Category: Nishino, T.]]
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[[Category: Nakayama T]]
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[[Category: Sekiguchi, S.]]
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[[Category: Nishino T]]
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[[Category: Unno, H.]]
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[[Category: Sekiguchi S]]
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[[Category: Yamashita, S.]]
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[[Category: Unno H]]
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[[Category: Yoshida, N.]]
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[[Category: Yamashita S]]
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[[Category: Yoshimura, T.]]
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[[Category: Yoshida N]]
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[[Category: Flavoprotein]]
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[[Category: Yoshimura T]]
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[[Category: Fmn]]
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[[Category: Idi]]
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[[Category: Ipp]]
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[[Category: Isomerase]]
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[[Category: Isopentenyl diphosphate isomerase]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Nadp]]
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[[Category: Type 2]]
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Current revision

Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP.

PDB ID 2zrw

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