4fxd

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{{STRUCTURE_4fxd| PDB=4fxd | SCENE= }}
 
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===Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA===
 
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==Function==
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==Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA==
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[[http://www.uniprot.org/uniprot/DPOA_YEAST DPOA_YEAST]] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) consitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13.<ref>PMID:10898792</ref>
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<StructureSection load='4fxd' size='340' side='right'caption='[[4fxd]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fxd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxd OCA], [https://pdbe.org/4fxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxd RCSB], [https://www.ebi.ac.uk/pdbsum/4fxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLA_YEAST DPOLA_YEAST] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792).<ref>PMID:10898792</ref> <ref>PMID:22119860</ref> <ref>PMID:31488849</ref>
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==About this Structure==
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==See Also==
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[[4fxd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXD OCA].
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: DNA-directed DNA polymerase]]
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</StructureSection>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Large Structures]]
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[[Category: Kilkenny, M L.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Klinge, S.]]
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[[Category: Kilkenny ML]]
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[[Category: Maman, J D.]]
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[[Category: Klinge S]]
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[[Category: Pellegrini, L.]]
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[[Category: Maman JD]]
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[[Category: Perera, R L.]]
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[[Category: Pellegrini L]]
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[[Category: Torella, R.]]
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[[Category: Perera RL]]
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[[Category: Dna polymerase]]
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[[Category: Torella R]]
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[[Category: Dna replication]]
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[[Category: Transferase-dna-rna complex]]
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Current revision

Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA

PDB ID 4fxd

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