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4bjp

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'''Unreleased structure'''
 
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The entry 4bjp is ON HOLD until sometime in the future
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==Crystal structure of E. coli penicillin binding protein 3==
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<StructureSection load='4bjp' size='340' side='right'caption='[[4bjp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bjp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjp OCA], [https://pdbe.org/4bjp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjp RCSB], [https://www.ebi.ac.uk/pdbsum/4bjp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjp ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic tail and a single transmembrane helix. We have solved the crystal structure of a soluble form of PBP3 (PBP357-577) at 2.5 A revealing the two modules of high molecular weight class B PBPs, a carboxy terminal module exhibiting transpeptidase activity and an amino terminal module of unknown function. To gain additional insight, the PBP3 Val88-Ser165 subdomain (PBP388-165), for which the electron density is poorly defined in the PBP3 crystal, was produced and its structure solved by SAD phasing at 2.1 A. The structure shows a three dimensional domain swapping with a beta-strand of one molecule inserted between two strands of the paired molecule, suggesting a possible role in PBP357-577 dimerization.
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Authors: Sauvage, E., Joris, M., Herman, R., Kerff, F., Rocaboy, M., Charlier, P.
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Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli.,Sauvage E, Derouaux A, Fraipont C, Joris M, Herman R, Rocaboy M, Schloesser M, Dumas J, Kerff F, Nguyen-Disteche M, Charlier P PLoS One. 2014 May 29;9(5):e98042. doi: 10.1371/journal.pone.0098042. eCollection, 2014. PMID:24875494<ref>PMID:24875494</ref>
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Description: Crystal structure of E. coli penicillin binding protein 3
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bjp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Charlier P]]
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[[Category: Herman R]]
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[[Category: Joris M]]
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[[Category: Kerff F]]
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[[Category: Rocaboy M]]
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[[Category: Sauvage E]]

Current revision

Crystal structure of E. coli penicillin binding protein 3

PDB ID 4bjp

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OCA

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