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4k5a
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4k5a is ON HOLD Authors: Schilling, J., Schoeppe, J., Sauer, E. Description: First crystal structure of anti-apoptotic BCL-W in its closed conforma...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W== | |
| + | <StructureSection load='4k5a' size='340' side='right'caption='[[4k5a]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4k5a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K5A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k5a OCA], [https://pdbe.org/4k5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k5a RCSB], [https://www.ebi.ac.uk/pdbsum/4k5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k5a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL2_BOVIN B2CL2_BOVIN] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plueckthun A]] | ||
| + | [[Category: Sauer E]] | ||
| + | [[Category: Schilling J]] | ||
| + | [[Category: Schoeppe J]] | ||
Current revision
Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W
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