This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2f28
From Proteopedia
(Difference between revisions)
| (14 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2f28.jpg|left|200px]]<br /><applet load="2f28" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2f28, resolution 1.670Å" /> | ||
| - | '''Crystal Structure of the Human Sialidase Neu2 Q116E Mutant'''<br /> | ||
| - | == | + | ==Crystal Structure of the Human Sialidase Neu2 Q116E Mutant== |
| - | + | <StructureSection load='2f28' size='340' side='right'caption='[[2f28]], [[Resolution|resolution]] 1.67Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[2f28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F28 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f28 OCA], [https://pdbe.org/2f28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f28 RCSB], [https://www.ebi.ac.uk/pdbsum/2f28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f28 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds. |
| - | [[ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f28_consurf.spt"</scriptWhenChecked> |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f28 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chavas LMG]] | ||
| + | [[Category: Fusi P]] | ||
| + | [[Category: Kato R]] | ||
| + | [[Category: Monti E]] | ||
| + | [[Category: Tettamanti G]] | ||
| + | [[Category: Tringali C]] | ||
| + | [[Category: Venerando B]] | ||
| + | [[Category: Wakatsuki S]] | ||
Current revision
Crystal Structure of the Human Sialidase Neu2 Q116E Mutant
| |||||||||||
Categories: Homo sapiens | Large Structures | Chavas LMG | Fusi P | Kato R | Monti E | Tettamanti G | Tringali C | Venerando B | Wakatsuki S
