3nws

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{{STRUCTURE_3nws| PDB=3nws | SCENE= }}
 
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===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===
 
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{{ABSTRACT_PUBMED_20837709}}
 
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==Function==
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==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==
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[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
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<StructureSection load='3nws' size='340' side='right'caption='[[3nws]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3nws]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWS FirstGlance]. <br>
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[[3nws]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nws OCA], [https://pdbe.org/3nws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nws RCSB], [https://www.ebi.ac.uk/pdbsum/3nws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nws ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:020837709</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Harper, S.]]
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[[Category: Harper S]]
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[[Category: Johnson, F B.]]
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[[Category: Johnson FB]]
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[[Category: Mason, M.]]
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[[Category: Mason M]]
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[[Category: Mitchell, M T.]]
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[[Category: Mitchell MT]]
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[[Category: Skordalakes, E.]]
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[[Category: Skordalakes E]]
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[[Category: Smith, J S.]]
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[[Category: Smith JS]]
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[[Category: Speicher, D W.]]
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[[Category: Speicher DW]]
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[[Category: Cell cycle]]
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[[Category: Ob fold]]
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[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
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[[Category: Single stranded telomeric dna binding]]
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Current revision

Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13

PDB ID 3nws

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