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3nvx

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{{STRUCTURE_3nvx| PDB=3nvx | SCENE= }}
 
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===Molecular mechanism of guidance cue recognition===
 
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{{ABSTRACT_PUBMED_20727575}}
 
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==Function==
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==Molecular mechanism of guidance cue recognition==
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[[http://www.uniprot.org/uniprot/VA39_VACCC VA39_VACCC]] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of host plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection (By similarity).
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<StructureSection load='3nvx' size='340' side='right' caption='[[3nvx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccc Vaccc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nvn|3nvn]], [[3nvq|3nvq]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A39R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10249 VACCC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvx OCA], [http://pdbe.org/3nvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nvx RCSB], [http://www.ebi.ac.uk/pdbsum/3nvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SEMA_VACCC SEMA_VACCC]] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of host plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nvx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nvx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1. Both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers, in which the Semaphorin and PlexinC1 beta propellers interact in an edge-on, orthogonal orientation. Both binding interfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove in blade 3 of the PlexinC1 propeller. A39R appears to achieve Sema7A mimicry by preserving key Plexin-binding determinants seen in the mammalian Sema7A complex that have evolved to achieve higher affinity binding to the host-derived PlexinC1. The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plexins are activated by dimerization.
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==About this Structure==
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Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.,Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575<ref>PMID:20727575</ref>
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[[3nvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020727575</ref><references group="xtra"/><references/>
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</div>
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[[Category: Vaccinia virus]]
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<div class="pdbe-citations 3nvx" style="background-color:#fffaf0;"></div>
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[[Category: Chen, X.]]
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[[Category: Focia, P.]]
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==See Also==
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[[Category: Garcia, C.]]
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*[[Semaphorin|Semaphorin]]
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[[Category: He, X.]]
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== References ==
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[[Category: Juo, Z.]]
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<references/>
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[[Category: Liu, H.]]
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__TOC__
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[[Category: Shim, A.]]
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</StructureSection>
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[[Category: Vaccc]]
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[[Category: Chen, X]]
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[[Category: Focia, P]]
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[[Category: Garcia, C]]
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[[Category: He, X]]
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[[Category: Juo, Z]]
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[[Category: Liu, H]]
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[[Category: Shim, A]]
[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Viral protein]]
[[Category: Viral protein]]

Current revision

Molecular mechanism of guidance cue recognition

3nvx, resolution 2.00Å

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