This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3nth

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nth" [edit=sysop:move=sysop])
Current revision (16:51, 1 November 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3nth| PDB=3nth | SCENE= }}
 
-
===Crystal structure of Tudor and Aubergine [R13(me2s)] complex===
 
-
{{ABSTRACT_PUBMED_20713507}}
 
-
==Function==
+
==Crystal structure of Tudor and Aubergine [R13(me2s)] complex==
-
[[http://www.uniprot.org/uniprot/TUD_DROME TUD_DROME]] Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation.
+
<StructureSection load='3nth' size='340' side='right'caption='[[3nth]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3nth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nth OCA], [https://pdbe.org/3nth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nth RCSB], [https://www.ebi.ac.uk/pdbsum/3nth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nth ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TUD_DROME TUD_DROME] Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/3nth_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nth ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general.
-
==About this Structure==
+
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507<ref>PMID:20713507</ref>
-
[[3nth]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTH OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:020713507</ref><references group="xtra"/><references/>
+
</div>
 +
<div class="pdbe-citations 3nth" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
-
[[Category: Gong, W M.]]
+
[[Category: Large Structures]]
-
[[Category: Huang, Y.]]
+
[[Category: Gong WM]]
-
[[Category: Li, Z Z.]]
+
[[Category: Huang Y]]
-
[[Category: Liu, H P.]]
+
[[Category: Li ZZ]]
-
[[Category: Xu, R M.]]
+
[[Category: Liu HP]]
-
[[Category: Germ cell formation]]
+
[[Category: Xu RM]]
-
[[Category: Ob-fold]]
+
-
[[Category: Transcription]]
+
-
[[Category: Tudor domain]]
+

Current revision

Crystal structure of Tudor and Aubergine [R13(me2s)] complex

PDB ID 3nth

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nth"
Personal tools