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3o6q
From Proteopedia
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| - | {{STRUCTURE_3o6q| PDB=3o6q | SCENE= }} | ||
| - | ===The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System=== | ||
| - | {{ABSTRACT_PUBMED_21147767}} | ||
| - | == | + | ==The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System== |
| - | [[http://www.uniprot.org/uniprot/SP2SA_BACSU SP2SA_BACSU | + | <StructureSection load='3o6q' size='340' side='right'caption='[[3o6q]], [[Resolution|resolution]] 2.50Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3o6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6Q FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6q OCA], [https://pdbe.org/3o6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6q RCSB], [https://www.ebi.ac.uk/pdbsum/3o6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6q ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SP2SA_BACSU SP2SA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.<ref>PMID:11371520</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Barak | + | [[Category: Large Structures]] |
| - | [[Category: Blagova | + | [[Category: Barak I]] |
| - | [[Category: Florek | + | [[Category: Blagova EV]] |
| - | [[Category: Lebedev | + | [[Category: Florek P]] |
| - | [[Category: Levdikov | + | [[Category: Lebedev AA]] |
| - | [[Category: Wilkinson | + | [[Category: Levdikov VM]] |
| - | + | [[Category: Wilkinson AJ]] | |
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Current revision
The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System
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