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3nwt
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| - | {{STRUCTURE_3nwt| PDB=3nwt | SCENE= }} | ||
| - | ===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13=== | ||
| - | {{ABSTRACT_PUBMED_20837709}} | ||
| - | == | + | ==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== |
| - | [[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST | + | <StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution|resolution]] 2.70Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWT FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [https://pdbe.org/3nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [https://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Harper | + | [[Category: Harper S]] |
| - | [[Category: Johnson | + | [[Category: Johnson FB]] |
| - | [[Category: Mason | + | [[Category: Mason M]] |
| - | [[Category: Mitchell | + | [[Category: Mitchell MT]] |
| - | [[Category: Skordalakes | + | [[Category: Skordalakes E]] |
| - | [[Category: Smith | + | [[Category: Smith JS]] |
| - | [[Category: Speicher | + | [[Category: Speicher DW]] |
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Current revision
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
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