3ngn

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{{STRUCTURE_3ngn| PDB=3ngn | SCENE= }}
 
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===Crystal structure of the human CNOT6L nuclease domain in complex with AMP===
 
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{{ABSTRACT_PUBMED_20628353}}
 
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==Function==
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==Crystal structure of the human CNOT6L nuclease domain in complex with AMP==
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[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
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<StructureSection load='3ngn' size='340' side='right'caption='[[3ngn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3ngn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGN FirstGlance]. <br>
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[[3ngn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngn OCA], [https://pdbe.org/3ngn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngn RCSB], [https://www.ebi.ac.uk/pdbsum/3ngn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngn ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020628353</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bartlam, M.]]
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[[Category: Large Structures]]
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[[Category: Morita, M.]]
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[[Category: Bartlam M]]
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[[Category: Rao, Z.]]
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[[Category: Morita M]]
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[[Category: Wang, H.]]
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[[Category: Rao Z]]
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[[Category: Yamamoto, T.]]
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[[Category: Wang H]]
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[[Category: Yang, W.]]
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[[Category: Yamamoto T]]
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[[Category: Hydrolase]]
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[[Category: Yang W]]
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[[Category: Protein-amp complex]]
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Current revision

Crystal structure of the human CNOT6L nuclease domain in complex with AMP

PDB ID 3ngn

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OCA

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