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| - | {{STRUCTURE_3nw0| PDB=3nw0 | SCENE= }}
| + | #REDIRECT [[5wy5]] This PDB entry is obsolete and replaced by 5wy5 |
| - | ===Crystal structure of MAGEG1 and NSE1 complex===
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| - | {{ABSTRACT_PUBMED_20864041}}
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/MAGG1_HUMAN MAGG1_HUMAN]] Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.<ref>PMID:20864041</ref> [[http://www.uniprot.org/uniprot/NSE1_HUMAN NSE1_HUMAN]] Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.<ref>PMID:18086888</ref> <ref>PMID:20864041</ref> | + | |
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| - | ==About this Structure==
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| - | [[3nw0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW0 OCA].
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| - | ==Reference==
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| - | <ref group="xtra">PMID:020864041</ref><references group="xtra"/><references/>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Gao, J.]]
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| - | [[Category: Yang, M.]]
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| - | [[Category: E3 ligase]]
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| - | [[Category: Metal binding protein]]
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| - | [[Category: Zn]]
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Current revision
- REDIRECT 5wy5 This PDB entry is obsolete and replaced by 5wy5
