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2fc6
From Proteopedia
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| - | [[Image:2fc6.gif|left|200px]]<br /><applet load="2fc6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fc6" /> | ||
| - | '''Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)'''<br /> | ||
| - | == | + | ==Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)== |
| - | + | <StructureSection load='2fc6' size='340' side='right'caption='[[2fc6]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc6 OCA], [https://pdbe.org/2fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc6 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Pontocerebellar hypoplasia type 7. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).<ref>PMID:12562764</ref> <ref>PMID:28092684</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Dang | + | [[Category: Dang W]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)
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Categories: Homo sapiens | Large Structures | Dang W | Inoue M | Kigawa T | Muto Y | Shirouzu M | Terada T | Yokoyama S
