We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Tubulin

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

References

↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Tubulin"

Category: Topic Page

@@ Line 1: / Line 1: @@
-[[Image:1z5w.png|left|200px|thumb|Crystal Structure of Tubulin [[1z5w]]]]
+<StructureSection load='' size='350' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
-{{STRUCTURE_1z5w|  PDB=1z5w  | SIZE=350| SCENE=Tubulin/Cv/1 |right|CAPTION= γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]] }}
+== Function ==
+[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes.  Tubulin filaments are stabilized by taxol and zampanolide.  '''FtsZ'''  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
+== Relevance ==
+The chemotherapeutic drug Taxol interacts with TUBB.  See [[Molecular Playground/Taxol]].  TUBA and TUBB expression in polyps of invasive colon cancer is different from normal<ref>PMID:16101133</ref>.
+See [[Paclitaxel]].
+== Disease ==
+Mutations in TUBB underlie a large spectrum of neuronal migration disorders<ref>PMID:19465910</ref>.
+== Structural highlights ==
+*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
-[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP.  γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes.  FtsZ  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, ''i.e.'' the crystal structure of Tubulin ([[1z5w]]).
-{{TOC limit|limit=2}}
 == 3D Structures of Tubulin ==
+[[Tubulin 3D Structures]]
-''Update February 2013''
+</StructureSection>
-=== Tubulin ===
-===α-tubulin===
-[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br />
-===α-tubulin + β-tubulin===
-[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]] – sTUBA+sTUBB+stathmin-like protein B3 – sheep<br />
-[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br />
-[[3ut5]] - sTUBA+sTUBB+stathmin-like protein B3 + vinca peptide<br />
-[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
-[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
-[[2wbe]] – cTUBA1D+cTUBB2B+kinesin+AMPPNP – cow<br />
-[[3dco]] - cTUBA+cTUBB+kinesin-like NOD<br />
-[[1tvk]] - cTUBA+cTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
-[[3iz0]] - cTUBA+cTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
-[[3edl]] - cTUBA1D+cTUBB2B+kinesin motor domain<br />
-[[2xrp]] - cTUBA1D+cTUBB2B+doublecortin <br />
-[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]] – cTUBA1C+cTUBB2B+stathmin-like protein B3<br />
-[[1ffx]] - cTUBA+cTUBB+stathmin-like protein B3<br />
-[[1jff]] - cTUBA+cTUBB<br />
-[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br />
-[[2hxf]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig<br />
-[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
-[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
-[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
-[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
-[[4aqv]], [[4aqw]] - bTUBA+bTUBB+kinesin-like KIF11 – bovine – Cryo EM<br />
-[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
-[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
-[[2btq]] – PdTUBA+PdTUBB<br />
-[[4ffb]] - TUBA+TUBB (mutant) + protein STU2 - yeast
-===γ-tubulin===
-[[3cb2]] – hTUBG1+GDP<br />
-[[1z5v]] - hTUBG1+GTPgS<br />
-[[1z5w]] - hTUBG1+GTP<br />
-=== FtsZ ===
-[[2rhh]], [[2rhj]] – BsFtsZ+SO4 – ''Bacillus subtilis''<br />
-[[2rhl]] - BsFtsZ+GDP<br />
-[[2rho]] - BsFtsZ+GDP+GTP-gamma-S<br />
-[[2vxy]], [[2vam]] – BsFtsZ<br />
-[[2ve8]] – PaFtsZ gamma domain – ''Pseudomonas aeruginosa''<br />
-[[2ve9]] - PaFtsZ gamma domain+DNA<br />
-[[2vaw]] – PaFtsZ+GDP<br />
-[[1ofu]] - PaFtsZ+SULA<br />
-[[2r75]] - AaFtsZ+8-morpholino-GTP – ''Aquifex aeolicus''<br />
-[[2r6r]] - AaFtsZ<br />
-[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br />
-[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br />
-[[1rq7]] - MtFtsZ+GDP<br />
-[[2vap]] – MjFtsZ+GDP – ''Methancaldococcus jannaschii''<br />
-[[1w58]] - MjFtsZ+GMPCPP<br />
-[[1w59]], [[1fsz]] – MjFtsZ<br />
-[[1w5a]] - MjFtsZ+MgGTP<br />
-[[1w5b]] - MjFtsZ+GTP<br />
-[[1w5e]], [[1w5f]] – MjFtsZ (mutant)
+== References ==
+<references/>
 [[Category:Topic Page]]

Tubulin

From Proteopedia

Current revision

Contents

Function

Relevance

Disease

Structural highlights

3D Structures of Tubulin

References

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox