3ldh
From Proteopedia
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| - | {{STRUCTURE_3ldh| PDB=3ldh | SCENE= }} | ||
| - | ===A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes=== | ||
| - | == | + | ==A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes== |
| - | [[3ldh]] is a 1 chain structure with sequence from [ | + | <StructureSection load='3ldh' size='340' side='right'caption='[[3ldh]], [[Resolution|resolution]] 3.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ldh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Squalus_acanthias Squalus acanthias]. The June 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lactate Dehydrogenase'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_6 10.2210/rcsb_pdb/mom_2008_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldh OCA], [https://pdbe.org/3ldh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldh RCSB], [https://www.ebi.ac.uk/pdbsum/3ldh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LDHA_SQUAC LDHA_SQUAC] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ldh_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ldh ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Lactate | + | *[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Lactate Dehydrogenase]] | [[Category: Lactate Dehydrogenase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Squalus acanthias]] | [[Category: Squalus acanthias]] | ||
| - | [[Category: Adams | + | [[Category: Adams MJ]] |
| - | [[Category: Buehner | + | [[Category: Buehner M]] |
| - | [[Category: Ford | + | [[Category: Ford GC]] |
| - | [[Category: Hackert | + | [[Category: Hackert ML]] |
| - | [[Category: Lentzjunior | + | [[Category: Lentzjunior PJ]] |
| - | [[Category: Rossmann | + | [[Category: Rossmann MG]] |
| - | [[Category: Smiley | + | [[Category: Smiley IE]] |
| - | [[Category: Steindel | + | [[Category: Steindel SJ]] |
| - | [[Category: White | + | [[Category: White JL]] |
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Current revision
A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes
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