2fg5

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[[Image:2fg5.gif|left|200px]]<br /><applet load="2fg5" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2fg5, resolution 2.801&Aring;" />
 
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'''Crystal structure of human RAB31 in complex with a GTP analogue'''<br />
 
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==About this Structure==
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==Crystal structure of human RAB31 in complex with a GTP analogue==
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2FG5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GNP:'>GNP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA].
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<StructureSection load='2fg5' size='340' side='right'caption='[[2fg5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance]. <br>
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[[Category: Arrowsmith, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
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[[Category: Bochkarev, A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Edwards, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fg5 OCA], [https://pdbe.org/2fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fg5 ProSAT]</span></td></tr>
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[[Category: Ismail, S.]]
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</table>
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[[Category: Park, H.]]
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== Function ==
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[[Category: SGC, Structural Genomics Consortium.]]
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[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>
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[[Category: Sundstrom, M.]]
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== Evolutionary Conservation ==
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[[Category: Tempel, W.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Wang, J.]]
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Check<jmol>
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[[Category: Weigelt, J.]]
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<jmolCheckbox>
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[[Category: GNP]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/2fg5_consurf.spt"</scriptWhenChecked>
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[[Category: MG]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: g-protein]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: gtp analogue]]
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</jmolCheckbox>
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[[Category: rab]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fg5 ConSurf].
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[[Category: sgc]]
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<div style="clear:both"></div>
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:21:05 2008''
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards A]]
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[[Category: Ismail S]]
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[[Category: Park H]]
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[[Category: Sundstrom M]]
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[[Category: Tempel W]]
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[[Category: Wang J]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of human RAB31 in complex with a GTP analogue

PDB ID 2fg5

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