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4kdq
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4kdq is ON HOLD Authors: Lu, X., Shi, Y., Zhang, W., Zhang, Y., Qi, J., Gao, G.F. Description: Crystal structure of the hemagglutinin of A/Xinjiang...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus== | |
| + | <StructureSection load='4kdq' size='340' side='right'caption='[[4kdq]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kdq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Xinjiang/1/2006(H5N1)) Influenza A virus (A/Xinjiang/1/2006(H5N1))] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/Guangdong/174/04(H5N1)) Influenza A virus (A/chicken/Guangdong/174/04(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KDQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.604Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kdq OCA], [https://pdbe.org/4kdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kdq RCSB], [https://www.ebi.ac.uk/pdbsum/4kdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kdq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C5HMM2_9INFA C5HMM2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | ||
| - | + | ==See Also== | |
| - | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gao GF]] | ||
| + | [[Category: Lu X]] | ||
| + | [[Category: Qi J]] | ||
| + | [[Category: Shi Y]] | ||
| + | [[Category: Zhang W]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus
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Categories: Large Structures | Gao GF | Lu X | Qi J | Shi Y | Zhang W | Zhang Y
