3p9u
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| - | {{STRUCTURE_3p9u| PDB=3p9u | SCENE= }} | ||
| - | ===Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue=== | ||
| - | == | + | ==Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue== |
| - | [[3p9u]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3p9u' size='340' side='right'caption='[[3p9u]], [[Resolution|resolution]] 2.81Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P9U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p9u OCA], [https://pdbe.org/3p9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p9u RCSB], [https://www.ebi.ac.uk/pdbsum/3p9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p9u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have determined the structure of Bacteroides thetaiotaomicron TetX2 at 2.8 A resolution, and shown that it is a class A flavin dependent oxidoreductase. TetX2 has broad activity against a range of tetracyclines including one of the most recent tetracyclines, tigecycline (Tygacil((R))). Comparison of TetX2 with that of the weakly homologous Pseudomonas fluorescens para-hydroxybenzoate hydroxylase (PHBH) (21% identity) shows substantial differences among residues at the substrate binding site although FAD is positioned in a similar conformation between the two enzymes and is poised to carry out catalysis. | ||
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| + | Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution.,Walkiewicz K, Davlieva M, Wu G, Shamoo Y Proteins. 2011 Jul;79(7):2335-40. doi: 10.1002/prot.23052. Epub 2011 May 16. PMID:21590745<ref>PMID:21590745</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3p9u" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bacteroides thetaiotaomicron]] | [[Category: Bacteroides thetaiotaomicron]] | ||
| - | [[Category: Davlieva | + | [[Category: Large Structures]] |
| - | [[Category: Lau | + | [[Category: Davlieva M]] |
| - | [[Category: Shamoo | + | [[Category: Lau K]] |
| - | [[Category: Sun | + | [[Category: Shamoo Y]] |
| - | [[Category: Walkiewicz | + | [[Category: Sun C]] |
| - | + | [[Category: Walkiewicz K]] | |
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| - | + | ||
Current revision
Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue
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