3oln
From Proteopedia
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| - | {{STRUCTURE_3oln| PDB=3oln | SCENE= }} | ||
| - | ===Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF2=== | ||
| - | == | + | ==Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF2== |
| - | [[3oln]] is a 2 chain structure with sequence from [ | + | <StructureSection load='3oln' size='340' side='right'caption='[[3oln]], [[Resolution|resolution]] 2.30Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3oln]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oln OCA], [https://pdbe.org/3oln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oln RCSB], [https://www.ebi.ac.uk/pdbsum/3oln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oln ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | + | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Avvakumov | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Avvakumov GV]] |
| - | [[Category: Bountra | + | [[Category: Bochkarev A]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Dhe-Paganon S]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Walker | + | [[Category: Walker JR]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Xue | + | [[Category: Xue S]] |
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Current revision
Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF2
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