3p6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:49, 6 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3p6a| PDB=3p6a | SCENE= }}
 
-
===Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)===
 
-
==Function==
+
==Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)==
-
[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
+
<StructureSection load='3p6a' size='340' side='right'caption='[[3p6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3p6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6A FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6a OCA], [https://pdbe.org/3p6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6a RCSB], [https://www.ebi.ac.uk/pdbsum/3p6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
-
==About this Structure==
+
==See Also==
-
[[3p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA].
+
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chen, Z.]]
+
[[Category: Large Structures]]
-
[[Category: Guo, L.]]
+
[[Category: Chen Z]]
-
[[Category: Sprang, S R.]]
+
[[Category: Guo L]]
-
[[Category: Sternweis, P C.]]
+
[[Category: Sprang SR]]
-
[[Category: Dh]]
+
[[Category: Sternweis PC]]
-
[[Category: Ph]]
+
-
[[Category: Regulation of rhoa gtpase]]
+
-
[[Category: Rho]]
+
-
[[Category: Rhogef]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)

PDB ID 3p6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p6a"
Personal tools