3p13
From Proteopedia
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| - | {{STRUCTURE_3p13| PDB=3p13 | SCENE= }} | ||
| - | ===Complex Structure of D-ribose Pyranase Sa240 with D-ribose=== | ||
| - | {{ABSTRACT_PUBMED_21276853}} | ||
| - | == | + | ==Complex Structure of D-ribose Pyranase Sa240 with D-ribose== |
| - | [[3p13]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3p13' size='340' side='right'caption='[[3p13]], [[Resolution|resolution]] 2.35Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p13]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P13 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIP:RIBOSE(PYRANOSE+FORM)'>RIP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p13 OCA], [https://pdbe.org/3p13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p13 RCSB], [https://www.ebi.ac.uk/pdbsum/3p13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p13 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBSD_STAA8 RBSD_STAA8] Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.[HAMAP-Rule:MF_01661] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ribose is transported into cells in its pyranose form and must be rearranged to its furanose form for further utilization. Ribose pyranase RbsD catalyzes the conversion of ribose from the pyranose to furanose form. This is the key step for substrate supply to ribokinase RbsK, which converts ribose to ribose-5-phosphate for further metabolism. Sequence analysis indicated Sa240 from Staphylococcus aureus was a ribose pyranase homolog. Here we showed that Sa240 formed dimeric structure both in solution and in crystal. S240-ribose complex structure showed a ribose binding site formed by an incomplete active site compared with RbsD. Because the catalytic activity of ribose pyranase depends on its oligomeric state, we propose Sa240 is catalytically inactive in its dimeric structure. | ||
| - | + | Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus.,Wang L, Wu M, Zang J J Struct Biol. 2011 May;174(2):413-9. Epub 2011 Jan 27. PMID:21276853<ref>PMID:21276853</ref> | |
| - | <ref | + | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 3p13" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Staphylococcus aureus subsp. aureus NCTC 8325]] | |
| + | [[Category: Wang L]] | ||
| + | [[Category: Wu M]] | ||
| + | [[Category: Zang J]] | ||
Current revision
Complex Structure of D-ribose Pyranase Sa240 with D-ribose
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