3izq
From Proteopedia
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| - | {{STRUCTURE_3izq| PDB=3izq | SCENE= }} | ||
| - | ===Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome=== | ||
| - | {{ABSTRACT_PUBMED_21623367}} | ||
| - | == | + | ==Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome== |
| - | [[http://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST | + | <SX load='3izq' size='340' side='right' viewer='molstar' caption='[[3izq]], [[Resolution|resolution]] 9.50Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3izq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZQ FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izq OCA], [https://pdbe.org/3izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izq RCSB], [https://www.ebi.ac.uk/pdbsum/3izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izq ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST] Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.<ref>PMID:16554824</ref> <ref>PMID:17889667</ref> <ref>PMID:18180287</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Anger | + | [[Category: Abdel Motaal B]] |
| - | [[Category: Armache | + | [[Category: Anger AM]] |
| - | [[Category: Becker | + | [[Category: Armache J-P]] |
| - | [[Category: Beckmann | + | [[Category: Becker T]] |
| - | [[Category: Berninghausen | + | [[Category: Beckmann R]] |
| - | [[Category: Jarasch | + | [[Category: Berninghausen O]] |
| - | [[Category: Mielke | + | [[Category: Jarasch A]] |
| - | + | [[Category: Mielke T]] | |
| - | [[Category: Sieber | + | [[Category: Sieber H]] |
| - | [[Category: Villa | + | [[Category: Villa E]] |
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Current revision
Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome
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