2fy1
From Proteopedia
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| - | [[Image:2fy1.gif|left|200px]]<br /><applet load="2fy1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fy1" /> | ||
| - | '''A dual mode of RNA recognition by the RBMY protein'''<br /> | ||
| - | == | + | ==A dual mode of RNA recognition by the RBMY protein== |
| - | + | <StructureSection load='2fy1' size='340' side='right'caption='[[2fy1]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2fy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FY1 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fy1 OCA], [https://pdbe.org/2fy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fy1 RCSB], [https://www.ebi.ac.uk/pdbsum/2fy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fy1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBY1A_HUMAN RBY1A_HUMAN] RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<ref>PMID:8269511</ref> <ref>PMID:12165565</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fy1_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fy1 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Allain | + | [[Category: Synthetic construct]] |
| - | [[Category: Bourgois | + | [[Category: Allain FHT]] |
| - | [[Category: Elliot | + | [[Category: Bourgois C]] |
| - | [[Category: Kister | + | [[Category: Elliot D]] |
| - | [[Category: Skrisovska | + | [[Category: Kister L]] |
| - | [[Category: Stefl | + | [[Category: Skrisovska L]] |
| - | [[Category: Stevenin | + | [[Category: Stefl R]] |
| - | [[Category: Wenter | + | [[Category: Stevenin J]] |
| - | + | [[Category: Wenter P]] | |
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Current revision
A dual mode of RNA recognition by the RBMY protein
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