2g0d

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[[Image:2g0d.gif|left|200px]]<br /><applet load="2g0d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2g0d, resolution 2.21&Aring;" />
 
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'''Nisin cyclase'''<br />
 
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==Overview==
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==Nisin cyclase==
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Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
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<StructureSection load='2g0d' size='340' side='right'caption='[[2g0d]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2g0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0D FirstGlance]. <br>
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2G0D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0d OCA], [https://pdbe.org/2g0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0d RCSB], [https://www.ebi.ac.uk/pdbsum/2g0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0d ProSAT]</span></td></tr>
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Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16527981 16527981]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NISC_LACLL NISC_LACLL] Could be implicated in the processing or the export process of the nisin lantibiotic.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g0d ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Lactococcus lactis subsp. lactis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Nair, S K.]]
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[[Category: Nair SK]]
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[[Category: ZN]]
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[[Category: alpha barrel]]
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[[Category: alpha toroid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:56 2008''
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Current revision

Nisin cyclase

PDB ID 2g0d

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