4bkw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4bkw is ON HOLD Authors: Williams, E., Krojer, T., Vollmar, M., Shrestha, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the C-terminal region of human ZFYVE9== | |
| - | + | <StructureSection load='4bkw' size='340' side='right'caption='[[4bkw]], [[Resolution|resolution]] 2.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4bkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BKW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkw OCA], [https://pdbe.org/4bkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bkw RCSB], [https://www.ebi.ac.uk/pdbsum/4bkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bkw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZFYV9_HUMAN ZFYV9_HUMAN] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.<ref>PMID:9865696</ref> <ref>PMID:15356634</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bullock A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Shrestha L]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Williams E]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the C-terminal region of human ZFYVE9
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bullock A | Edwards AM | Krojer T | Shrestha L | Vollmar M | Williams E | Von Delft F
