4k6j

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'''Unreleased structure'''
 
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The entry 4k6j is ON HOLD
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==Human cohesin inhibitor WapL==
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<StructureSection load='4k6j' size='340' side='right'caption='[[4k6j]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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Authors: Tomchick, D.R., Yu, H., Ouyang, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k6j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K6J FirstGlance]. <br>
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Description: Human cohesin inhibitor WapL
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6205&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6j OCA], [https://pdbe.org/4k6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k6j RCSB], [https://www.ebi.ac.uk/pdbsum/4k6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WAPL_HUMAN WAPL_HUMAN] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.<ref>PMID:15150110</ref> <ref>PMID:17113138</ref> <ref>PMID:17112726</ref> <ref>PMID:19696148</ref> <ref>PMID:19907496</ref> <ref>PMID:21111234</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ouyang Z]]
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[[Category: Tomchick DR]]
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[[Category: Yu H]]

Current revision

Human cohesin inhibitor WapL

PDB ID 4k6j

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