4khp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4khp is ON HOLD Authors: Tourigny, D.S., Fernandez, I.S., Kelley, A.C., Ramakrishnan, V. Description: Structure of the Thermus thermophilus 30S rib...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin== | |
| + | <StructureSection load='4khp' size='340' side='right'caption='[[4khp]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4khp]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KHP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=PCY:PACTAMYCIN'>PCY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4khp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4khp OCA], [https://pdbe.org/4khp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4khp RCSB], [https://www.ebi.ac.uk/pdbsum/4khp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4khp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RSHX_THET8 RSHX_THET8] Binds at the top of the head of the 30S subunit. It stabilizes a number of different RNA elements and thus is important for subunit structure. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as potential antiprotozoal and antitumor drugs. Here, we report a 3.1-A crystal structure of de-6-MSA-pactamycin bound to its target site on the Thermus thermophilus 30S ribosomal subunit. Although de-6-MSA-pactamycin lacks the MSA moiety, it shares the same binding site as pactamycin and induces a displacement of nucleic acid template bound at the E-site of the 30S. The structure highlights unique interactions between this pactamycin analog and the ribosome, which paves the way for therapeutic development of related compounds. | ||
| - | + | Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit.,Tourigny DS, Fernandez IS, Kelley AC, Vakiti RR, Chattopadhyay AK, Dorich S, Hanessian S, Ramakrishnan V J Mol Biol. 2013 May 20. pii: S0022-2836(13)00303-3. doi:, 10.1016/j.jmb.2013.05.004. PMID:23702293<ref>PMID:23702293</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4khp" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]] | ||
| + | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermus thermophilus HB8]] | ||
| + | [[Category: Fernandez IS]] | ||
| + | [[Category: Kelley AC]] | ||
| + | [[Category: Ramakrishnan V]] | ||
| + | [[Category: Tourigny DS]] | ||
Current revision
Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin
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