2g86
From Proteopedia
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| - | [[Image:2g86.gif|left|200px]]<br /><applet load="2g86" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2g86, resolution 2.40Å" /> | ||
| - | '''L. casei thymidylate synthase Y261F in complex with substrate, dUMP'''<br /> | ||
| - | == | + | ==L. casei thymidylate synthase Y261F in complex with substrate, dUMP== |
| - | + | <StructureSection load='2g86' size='340' side='right'caption='[[2g86]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2g86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G86 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g86 OCA], [https://pdbe.org/2g86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g86 RCSB], [https://www.ebi.ac.uk/pdbsum/2g86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g86 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [ | + | == Function == |
| - | [[ | + | [https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis. |
| - | [ | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g86_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g86 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lacticaseibacillus casei]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Finer-Moore JS]] | ||
| + | [[Category: Stroud RM]] | ||
Current revision
L. casei thymidylate synthase Y261F in complex with substrate, dUMP
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