4kfo

{{STRUCTURE_4kfo| PDB=4kfo | SCENE= }}

===Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===

{{ABSTRACT_PUBMED_23617784}}

==Function==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

==About this Structure==

[[4kfo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFO OCA].

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Bair, K W.]]

[[Category: Bauer, P.]]

[[Category: Baumeister, T.]]

[[Category: Brien, T O.]]

[[Category: Buckmelter, A J.]]

[[Category: Caligiuri, M.]]

[[Category: Clodfelter, K H.]]

[[Category: Dragovich, P S.]]

[[Category: Gunzner-Tosteb, J.]]

[[Category: Han, B.]]

[[Category: Ho, Y.]]

[[Category: Kley, N.]]

[[Category: Liederer, B M.]]

[[Category: Lin, J.]]

[[Category: Ly, J.]]

[[Category: Oh, A.]]

[[Category: Reynolds, D J.]]

[[Category: Sharma, G.]]

[[Category: Smith, C C.]]

[[Category: Wang, L.]]

[[Category: Wang, W.]]

[[Category: Wang, Z.]]

[[Category: Xiao, Y.]]

[[Category: Yuen, P.]]

[[Category: Zak, M.]]

[[Category: Zhao, G.]]

[[Category: Zheng, X.]]

[[Category: Transferase-transferase inhibitor complex]]