2g8y
From Proteopedia
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| - | [[Image:2g8y.gif|left|200px]]<br /><applet load="2g8y" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2g8y, resolution 2.15Å" /> | ||
| - | '''The structure of a putative malate/lactate dehydrogenase from E. coli.'''<br /> | ||
| - | == | + | ==The structure of a putative malate/lactate dehydrogenase from E. coli.== |
| - | + | <StructureSection load='2g8y' size='340' side='right'caption='[[2g8y]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2g8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8Y FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8y OCA], [https://pdbe.org/2g8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8y RCSB], [https://www.ebi.ac.uk/pdbsum/2g8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8y ProSAT], [https://www.topsan.org/Proteins/MCSG/2g8y TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/HCXB_ECOLI HCXB_ECOLI] Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions.<ref>PMID:27941785</ref> |
| - | [ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8y_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8y ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
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| - | [ | + | |
| - | [[ | + | |
| - | [ | + | |
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| - | + | ||
| - | + | ==See Also== | |
| + | *[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cuff ME]] | ||
| + | [[Category: Cymborowski M]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Minor W]] | ||
| + | [[Category: Savchenko A]] | ||
| + | [[Category: Skarina T]] | ||
Current revision
The structure of a putative malate/lactate dehydrogenase from E. coli.
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