3q0p

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{{STRUCTURE_3q0p| PDB=3q0p | SCENE= }}
 
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===Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with hunchback NRE===
 
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{{ABSTRACT_PUBMED_021397187}}
 
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==Function==
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==Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with hunchback NRE==
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[[http://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
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<StructureSection load='3q0p' size='340' side='right'caption='[[3q0p]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3q0p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0P FirstGlance]. <br>
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[[3q0p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0P OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0p OCA], [https://pdbe.org/3q0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0p RCSB], [https://www.ebi.ac.uk/pdbsum/3q0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hall, T M.T.]]
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[[Category: Large Structures]]
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[[Category: Lu, G.]]
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[[Category: Hall TMT]]
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[[Category: Gene regulation]]
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[[Category: Lu G]]
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[[Category: Puf]]
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[[Category: Pumilio-homolgy domain]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein-rna complex]]
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Current revision

Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with hunchback NRE

PDB ID 3q0p

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