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3q7k

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{{STRUCTURE_3q7k| PDB=3q7k | SCENE= }}
 
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===Formate Channel FocA from Salmonella typhimurium===
 
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{{ABSTRACT_PUBMED_21493860}}
 
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==About this Structure==
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==Formate Channel FocA from Salmonella typhimurium==
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[[3q7k]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7K OCA].
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<StructureSection load='3q7k' size='340' side='right'caption='[[3q7k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q7k]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi_str._CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7k OCA], [https://pdbe.org/3q7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7k RCSB], [https://www.ebi.ac.uk/pdbsum/3q7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7CQU0_SALTY Q7CQU0_SALTY]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The formate transporter FocA was described to switch its mode of operation from a passive export channel at high external pH to a secondary active formate/H(+) importer at low pH. The crystal structure of Salmonella typhimurium FocA at pH 4.0 shows that this switch involves a major rearrangement of the amino termini of individual protomers in the pentameric channel. The amino-terminal helices open or block transport in a concerted, cooperative action that indicates how FocA is gated in a pH-dependent way. Electrophysiological studies show that the protein acts as a specific formate channel at pH 7.0 and that it closes upon a shift of pH to 5.1.
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==Reference==
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pH-dependent gating in a FocA formate channel.,Lu W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O Science. 2011 Apr 15;332(6027):352-4. PMID:21493860<ref>PMID:21493860</ref>
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<ref group="xtra">PMID:021493860</ref><references group="xtra"/><references/>
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[[Category: Salmonella enterica subsp. enterica serovar typhi]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Andrade, S L.A.]]
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</div>
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[[Category: Du, J.]]
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<div class="pdbe-citations 3q7k" style="background-color:#fffaf0;"></div>
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[[Category: Einsle, O.]]
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== References ==
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[[Category: Gerbig-Smentek, E.]]
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<references/>
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[[Category: Lue, W.]]
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__TOC__
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[[Category: Wacker, T.]]
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</StructureSection>
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[[Category: Cytoplasmic membrane]]
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[[Category: Large Structures]]
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[[Category: Membrane protein]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhi str. CT18]]
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[[Category: Transport]]
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[[Category: Andrade SLA]]
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[[Category: Transport protein]]
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[[Category: Du J]]
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[[Category: Einsle O]]
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[[Category: Gerbig-Smentek E]]
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[[Category: Lue W]]
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[[Category: Wacker T]]

Current revision

Formate Channel FocA from Salmonella typhimurium

PDB ID 3q7k

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