3px3

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{{STRUCTURE_3px3| PDB=3px3 | SCENE= }}
 
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===Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N===
 
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{{ABSTRACT_PUBMED_21142177}}
 
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==Function==
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==Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N==
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[[http://www.uniprot.org/uniprot/P95748_STRFR P95748_STRFR]] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>
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<StructureSection load='3px3' size='340' side='right'caption='[[3px3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3px3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PX3 FirstGlance]. <br>
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[[3px3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX3 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T3Q:[(3R,4S,5S,6R)-4-AMINO-3,5-DIHYDROXY-6-METHYLOXAN-2-YL][HYDROXY-[[(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXOPYRIMIDIN-1-YL)OXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>T3Q</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3px3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3px3 OCA], [https://pdbe.org/3px3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3px3 RCSB], [https://www.ebi.ac.uk/pdbsum/3px3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3px3 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:021142177</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces fradiae]]
[[Category: Streptomyces fradiae]]
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[[Category: Carney, A E.]]
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[[Category: Carney AE]]
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[[Category: Holden, H M.]]
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[[Category: Holden HM]]
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[[Category: Dtdp-quip3n binding]]
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[[Category: N-dimethyltransferase]]
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[[Category: Sam binding]]
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[[Category: Transferase]]
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Current revision

Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N

PDB ID 3px3

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