This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3q93

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:37, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3q93| PDB=3q93 | SCENE= }}
 
-
===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===
 
-
==Function==
+
==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==
-
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+
<StructureSection load='3q93' size='340' side='right'caption='[[3q93]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [https://pdbe.org/3q93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [https://www.ebi.ac.uk/pdbsum/3q93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q93 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
-
==About this Structure==
+
==See Also==
-
[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].
+
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Berg, S Van Der.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berglund, H.]]
+
[[Category: Berglund H]]
-
[[Category: Bountra, C.]]
+
[[Category: Bountra C]]
-
[[Category: Collins, R.]]
+
[[Category: Collins R]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: Ekblad, T.]]
+
[[Category: Ekblad T]]
-
[[Category: Flodin, S.]]
+
[[Category: Flodin S]]
-
[[Category: Flores, A.]]
+
[[Category: Flores A]]
-
[[Category: Graslund, S.]]
+
[[Category: Graslund S]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Johansson, I.]]
+
[[Category: Johansson I]]
-
[[Category: Karlberg, T.]]
+
[[Category: Karlberg T]]
-
[[Category: Kol, S.]]
+
[[Category: Kol S]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Kouznetsova, E.]]
+
[[Category: Kouznetsova E]]
-
[[Category: Moche, M.]]
+
[[Category: Moche M]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nordlund P]]
-
[[Category: Nyman, T.]]
+
[[Category: Nyman T]]
-
[[Category: Persson, C.]]
+
[[Category: Persson C]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Schuler H]]
-
[[Category: Schuler, H.]]
+
[[Category: Schutz P]]
-
[[Category: Schutz, P.]]
+
[[Category: Siponen MI]]
-
[[Category: Siponen, M I.]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Tresaugues L]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Van Der Berg S]]
-
[[Category: Wahlberg, E.]]
+
[[Category: Wahlberg E]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, M.]]
+
[[Category: Welin M]]
-
[[Category: Hydrolase]]
+
-
[[Category: Magnesium binding]]
+
-
[[Category: Mutt-like]]
+
-
[[Category: Nudix]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

Crystal Structure of Human 8-oxo-dGTPase (MTH1)

PDB ID 3q93

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3q93"
Personal tools