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3qb5

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{{STRUCTURE_3qb5| PDB=3qb5 | SCENE= }}
 
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===Human C3PO complex in the presence of MnSO4===
 
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{{ABSTRACT_PUBMED_21552258}}
 
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==Function==
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==Human C3PO complex in the presence of MnSO4==
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[[http://www.uniprot.org/uniprot/TSN_HUMAN TSN_HUMAN]] DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> [[http://www.uniprot.org/uniprot/TSNAX_HUMAN TSNAX_HUMAN]] Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.<ref>PMID:12036294</ref> <ref>PMID:21552258</ref>
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<StructureSection load='3qb5' size='340' side='right'caption='[[3qb5]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3qb5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QB5 FirstGlance]. <br>
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[[3qb5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qb5 OCA], [https://pdbe.org/3qb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qb5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qb5 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:021552258</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSN_HUMAN TSN_HUMAN] DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, S.]]
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[[Category: Large Structures]]
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[[Category: Huang, N.]]
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[[Category: Chen S]]
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[[Category: Liu, Q.]]
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[[Category: Huang N]]
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[[Category: Liu, Y.]]
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[[Category: Liu Q]]
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[[Category: Paroo, Z.]]
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[[Category: Liu Y]]
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[[Category: Ye, X.]]
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[[Category: Paroo Z]]
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[[Category: Zhang, H.]]
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[[Category: Ye X]]
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[[Category: 7 alpha helical bundle]]
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[[Category: Zhang H]]
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[[Category: Hydrolase]]
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[[Category: Ribonuclease]]
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Current revision

Human C3PO complex in the presence of MnSO4

PDB ID 3qb5

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