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3qiz

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{{STRUCTURE_3qiz| PDB=3qiz | SCENE= }}
 
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===Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2===
 
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{{ABSTRACT_PUBMED_21434688}}
 
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==Function==
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==Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2==
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[[http://www.uniprot.org/uniprot/BXA1_CLOBH BXA1_CLOBH]] Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
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<StructureSection load='3qiz' size='340' side='right'caption='[[3qiz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qiz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QI2:(2S,4R)-2-(2-{[3-(4-FLUORO-3-METHYLPHENYL)PROPYL](METHYL)AMINO}ETHYL)-4-(4-FLUOROPHENYL)-N-HYDROXY-4-METHOXYBUTANAMIDE'>QI2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiz OCA], [https://pdbe.org/3qiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qiz RCSB], [https://www.ebi.ac.uk/pdbsum/3qiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qiz ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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[[3qiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIZ OCA].
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021434688</ref><references group="xtra"/><references/>
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[[Category: Clostridium botulinum A str. Hall]]
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[[Category: Bontoxilysin]]
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[[Category: Large Structures]]
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[[Category: Clostridium botulinum]]
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[[Category: Han GW]]
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[[Category: Han, G W.]]
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[[Category: Stevens RC]]
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[[Category: Stevens, R C.]]
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[[Category: Thompson AA]]
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[[Category: Thompson, A A.]]
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[[Category: Bont]]
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[[Category: Botulinum]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydroxamate]]
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[[Category: Inhibitor]]
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[[Category: Metalloprotease]]
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[[Category: Neurotoxin]]
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[[Category: Protease]]
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[[Category: Toxin]]
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Current revision

Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2

PDB ID 3qiz

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