3q9e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:38, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3q9e| PDB=3q9e | SCENE= }}
 
-
===Crystal structure of H159A APAH complexed with acetylspermine===
 
-
{{ABSTRACT_PUBMED_21268586}}
 
-
==Function==
+
==Crystal structure of H159A APAH complexed with acetylspermine==
-
[[http://www.uniprot.org/uniprot/APHA_MYCRA APHA_MYCRA]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides.
+
<StructureSection load='3q9e' size='340' side='right'caption='[[3q9e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[3q9e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplana_ramosa Mycoplana ramosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9E FirstGlance]. <br>
-
[[3q9e]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycoplana_ramosa Mycoplana ramosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9E OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SP5:N-[3-({4-[(3-AMINOPROPYL)AMINO]BUTYL}AMINO)PROPYL]ACETAMIDE'>SP5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9e OCA], [https://pdbe.org/3q9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9e RCSB], [https://www.ebi.ac.uk/pdbsum/3q9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9e ProSAT]</span></td></tr>
-
<ref group="xtra">PMID:021268586</ref><references group="xtra"/><references/>
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/APAH_MYCRA APAH_MYCRA] Involved in polyamine metabolism. Catalyzes the deacetylation of various acetylated polyamines such as N-acetylputrescine, N-acetylcadaverine, N(1)-acetylspermine, N(1)-acetylspermidine and N(8)-acetylspermidine (PubMed:8824626, PubMed:3207420). In vitro, is also able to deacetylate L-Lys(epsilon-acetyl)coumarin, but has very low activity towards the larger tetrapeptide N-acetyl-L-Arg-L-His-L-Lys(epsilon-acetyl)-L-Lys(epsilon-acetyl)coumarin (PubMed:21268586).<ref>PMID:21268586</ref> <ref>PMID:3207420</ref> <ref>PMID:8824626</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mycoplana ramosa]]
[[Category: Mycoplana ramosa]]
-
[[Category: Christianson, D W.]]
+
[[Category: Christianson DW]]
-
[[Category: Lombardi, P M.]]
+
[[Category: Lombardi PM]]
-
[[Category: Arginase fold]]
+
-
[[Category: Deacetylase]]
+
-
[[Category: Hdac]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Polyamine]]
+

Current revision

Crystal structure of H159A APAH complexed with acetylspermine

PDB ID 3q9e

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3q9e"
Personal tools