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3q4t
From Proteopedia
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| - | {{STRUCTURE_3q4t| PDB=3q4t | SCENE= }} | ||
| - | ===Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin=== | ||
| - | == | + | ==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin== |
| - | [[3q4t]] is a 2 chain structure with sequence from [ | + | <StructureSection load='3q4t' size='340' side='right'caption='[[3q4t]], [[Resolution|resolution]] 1.96Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3q4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q4T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAK:6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE'>TAK</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q4t OCA], [https://pdbe.org/3q4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q4t RCSB], [https://www.ebi.ac.uk/pdbsum/3q4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q4t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Alfano | + | [[Category: Alfano I]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Bullock | + | [[Category: Bullock A]] |
| - | [[Category: Chaikuad | + | [[Category: Chaikuad A]] |
| - | [[Category: Cooper | + | [[Category: Cooper CDO]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Edwards | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Mahajan P]] |
| - | [[Category: Mahajan | + | [[Category: Muniz JRC]] |
| - | [[Category: Muniz | + | [[Category: Raynor J]] |
| - | [[Category: Raynor | + | [[Category: Sanvitale C]] |
| - | + | [[Category: Vollmar M]] | |
| - | [[Category: Sanvitale | + | [[Category: Weigelt J]] |
| - | [[Category: Vollmar | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
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Categories: Homo sapiens | Large Structures | Alfano I | Arrowsmith CH | Bountra C | Bullock A | Chaikuad A | Cooper CDO | Edwards AM | Krojer T | Mahajan P | Muniz JRC | Raynor J | Sanvitale C | Vollmar M | Weigelt J | Von Delft F
